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KMID : 0378019740170081121
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New Medical Journal
1974 Volume.17 No. 8 p.1121 ~ p.1123
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THE EFFECT OF COMPOUND OF ACONITE AND SULFUR ON BLOOD ALCOHOL LEVEL IN RABBITS
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洪載奉/Hong, Jae-Bong
李雄烈/朴宗漢/李時炯/Lee, Woong-yul/Park, Jong-han/Lee, si-hyung
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Abstract
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We had found Gollin, a compound of aconite and sulfur, was quite effective in controlling hangover syndrome in the previous clinical study.
In this study, we have tried to explain the possible biological mechanism of its effectiveness, at least in part, by way of analyzing blood alcohol clearence rate.
Nature rabbits of both sexes, weighing between 2.0 kg and 3.0 kg were used. Experimental group was given five capsules of Gollin in liquid form 20 minutes prior to L V. injection of 50 Vol. % of ethanol in a dose of 5.0 ml/kg of body weight. All of the specimens. were obtained by cardiac pucture at 10 and 30 min. respectively after alcohol edmini￢stration.
The result showed blood alcohol clearence was much enhanced in the experimental group and it was more so at 10 min. than 30. A possible mechani￢sm for this finding. was discussed and this result was also related to the clinical effectiveness of Gollin in controlling hangover syndrome.
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